The Cadillac Escalade and Mercedes-Benz GLS are both three-row luxury SUVs, but they’re built very differently. The Escalade is a body-on-frame SUV with more third-row and cargo space, a V8 as standard and a dramatic curved OLED dashboard. The GLS, built in Alabama, is a unibody SUV that drives more like a car, with a beautifully finished cabin, strong inline-six and V8 engines and optional E-Active Body Control. For maximum space, the Escalade (especially the ESV) wins; for car-like refinement, the GLS.

At a glance

Cadillac Escalade Mercedes-Benz GLS
Construction Body-on-frame Unibody
Built in Arlington, Texas Tuscaloosa, Alabama
Seats 7–8 6–7
Third row Roomy Adequate
Cargo behind third row Larger (much larger in ESV) Smaller
Engines 6.2L V8, 3.0L diesel Inline-six (GLS 450), V8 (GLS 580), AMG
Ultra-luxury version Escalade-V (performance), Escalade IQ Mercedes-Maybach GLS

Space

The Escalade’s third row and cargo area are more generous — an important difference for airport runs with six people and luggage. Read luggage capacity by vehicle.

Driving and ride

The GLS feels lighter on its feet, with precise steering. Its available E-Active Body Control can counteract body roll and bumps. The Escalade is smooth and quiet, with a more commanding feel.

Interior

The GLS has Mercedes’ elegant materials and MBUX screens; the Escalade’s curved OLED display and AKG audio are standouts.

Verdict

For chauffeured groups with luggage, the Escalade’s space makes it the more practical choice. For a family that prioritizes driving refinement, the GLS is excellent. Read the Mercedes GLS, body-on-frame vs unibody and see our Cadillac Escalade.

Third-row reality

Adults can sit in the third row of both SUVs, but the Escalade’s third row is roomier and easier to reach, thanks to the independent rear suspension introduced in 2021 and a wider walkway between second-row captain’s chairs. The GLS’s power-folding seats are convenient, but tall adults will be more comfortable in the Escalade on longer trips.

Winter and weather

Both offer four-wheel or all-wheel drive, and both handle Northeast winters well with the right tires. The Escalade’s higher ground clearance helps in deep snow; the GLS’s lower, lighter unibody feels more planted on wet highways. Read AWD vs 4WD.

Fuel and range

The GLS’s inline-six mild hybrid is efficient for its size. The Escalade’s diesel option is the thriftiest on long highway trips, while its gasoline V8 prioritizes effortless power. Read diesel vs gas SUVs.